There are more than 180 species of fungi that produce psychedelic effects. These mushrooms contain psilocybin as an active ingredient.

At 30 minutes after consuming psilocybin, you can experience euphoria, visual and auditory hallucinations, increase in sensory perceptions, alterations in the perspectives of reality, time and space, and very deep states of introspection. In some cases, paranoia, anxiety, horror, and emotional instability may also occur.

The effects at the physical level include an increase in body temperature, gastrointestinal disturbances (especially nausea or vomiting), perceptive disorders, loss of balance, increased sensitivity, dilation of pupils, and dry mouth.

No cases of death due to overdose have been described since the organism itself rejects the substance through vomiting and does not allow the ingestion of large doses.

Recent studies have shown that psychedelic mushrooms have a positive effect in the treatment of depression. This is mainly due to the fact that psilocybin is able to stimulate the brain cells responsible for regulating mood.

A depressed brain does not work properly, but when psilocybin is consumed it restarts and the cognitive functions can improve. Patients use the terms “restarted” and “reborn” to describe their situation after consuming these products.

Monoamine oxidase inhibitors (MAOIs) are drugs with wide use in the treatment of depression, since they allow regulating the biochemical imbalance that exists in the brain of these patients.

Therefore, both substances have a common field; they are used as an antidepressant treatment. When combined, MAOIs intensify the effect of psychedelic mushrooms. Having consequences such as: 

  • Dry mouth
  • Nausea, diarrhea or constipation
  • Headache
  • Drowsiness
  • Insomnia
  • Dizziness or lightheadedness
  • Blurry vision
  • Colic
  • Low blood pressure
  • Difficulty starting to urinate
  • Muscle cramps
  • Tingling sensation  (paresthesia)
  • Seizures

Most importantly, a potentially fatal condition known as “serotonin syndrome,” can occur when MAOIs and MDMA or LSD are combined. For that reason, do not mix psychedelics with MAOIs.