Small Pharma Inc. (TSXV: DMT / OTCQB: DMTTF), a biotechnology company focused on short-duration psychedelic-assisted therapies for mental health conditions, today announces an update to its intellectual property (“IP“) portfolio, demonstrating significant progress already made by the Company in 2023.

Small Pharma aims to protect its pipeline programs through a multi-layered IP strategy with four core areas of protection. These areas of protection include: Composition of Matter, covering novel drug substances; Medical Use, covering therapeutic compositions and medical uses thereof; Drug Product, covering pharmaceutical formulations; and Synthetic Route, covering the novel and efficient synthesis of high purity drug substance at scale. 

Since the previous IP portfolio update on February 1, 2023, the Company has secured five new granted patents, with three more expected to be granted by May 31, 2023. Additionally, it has received five patent Notices of Allowance. The additional IP covers the four focused areas of protection and multiple markets, strengthening the Company’s international IP position.

The new patent grants and Notices of Allowance are summarized below. 

Patent
Protection
DescriptionMarketPatent No.Status
Composition of
Matter 







For certain deuterated homologues of certain tryptamine compoundsUSA11,578,039Granted
For certain deuterated homologues of certain tryptamine compoundsNew
Zealand
788543Granted
For certain deuterated analogues of N,N, dimethyltryptamine (“DMT”) GB2 592 822 Grant expected
after May 22, 2023
For a group of deuterated homologues of DMTUSA11,660,289Grant expected on
May 30, 2023
For a group of deuterated homologues of DMTEurope4 031 529Notice of
Allowance
Medical Use




Of certain deuterated analogues of DMT GB2 586 940Grant expected
after May 25, 2023
Medical use and therapeutic compositions of a group of deuterated homologues of DMT Australia2021204158Notice of
Allowance
Medical use and therapeutic compositions of a group of deuterated homologues of DMTNew Zealand794833Notice of
Allowance
Therapeutic compositions of a group of deuterated homologues of DMTJapan2022-574099Notice of
Allowance
Drug Product
Novel optimized injectable formulation of DMT based compoundsAustralia2021334933Granted
Therapeutic solid dosage forms of deuterated DMT analoguesGB2 595 776Granted
Synthetic Route 
Novel efficient synthesis of high purity DMT and deuterated DMT analogues at scaleUSA11,643,390Granted
Novel efficient synthesis of high purity DMT and deuterated DMT analogues at scaleCanada3160337Notice of
Allowance

As of May 24, 2023, Small Pharma’s IP portfolio consists of 19 granted patents, with 97 allowed or pending. The protection covering each of the Company’s pipeline programs is outlined below.

Candidate / ProjectRelevant Patents in Portfolio 
(No. active patents / pending patent applications)
SPL0261,  SPL0282, SPL02934 granted patents and 31 allowed and pending applications
SPL0286 granted patents, 37 allowed and pending applications
SPL028, SPL0298 allowed and pending applications
SPL029 4 granted patents, 11 allowed and pending applications
Non-psychedelic / othergranted patents, 10 allowed and pending applications

1Intravenous or intramuscular DMT
Injectable deuterated DMT series
Oral tryptamine series

“Our team has made great progress this year to further strengthen our proprietary IP position in key international markets. We continue to build multi-layered IP protection around each of our pipeline programs, helping to optimize their commercial potential. We are pleased that our efforts to invest in developing novel treatment innovations for patients continues to be recognized in multiple jurisdictions.”

George Tziras, Chief Executive Officer of Small Pharma

About Small Pharma

Small Pharma is a biotechnology company progressing a pipeline of short-duration psychedelic-assisted therapies for the treatment of mental health conditions. The Company’s current focus is on exploring new therapeutic approaches for depression. Small Pharma’s lead candidate, SPL026, is a proprietary synthetic formulation of N, N-dimethyltryptamine. The Company is advancing clinical programs of SPL026 and SPL028 with supportive therapy for the treatment of mental health conditions, and was granted an Innovation Passport designation from the U.K. Medicines and Healthcare products Regulatory Agency for IV SPL026 with supportive therapy for Major Depressive Disorder. In addition, Small Pharma has a pipeline of proprietary preclinical assets in development.